MicroRNAs in neuronal function and dysfunction.

Title
MicroRNAs in neuronal function and dysfunction.
Authors
임혜인Paul J. Kenny
Issue Date
2012-05
Publisher
TRENDS IN NEUROSCIENCES
Citation
VOL 35, NO 5, 325-334
Abstract
MicroRNAs (miRNAs) are small noncoding RNA transcripts expressed throughout the brain that can regulate neuronal gene expression at the post-transcriptional level. Here, we provide an overview of the role for miRNAs in brain development and function, and review evidence suggesting that dysfunction in miRNA signaling contributes to neurodevelopment disorders such as Rett and fragile X syndromes, as well as complex behavioral disorders including schizophrenia, depression and drug addiction. A better understanding of how miRNAs influence the development of neuropsychiatric disorders may reveal fundamental insights into the causes of these devastating illnesses and offer novel targets for therapeutic development.
URI
http://pubs.kist.re.kr/handle/201004/49312
ISSN
01662236
Appears in Collections:
KIST Publication > ETC
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE