Electrophysiological Analysis of Parkinson's Disease during Optical Deep Brain Stimulation in Mouse Model
- Electrophysiological Analysis of Parkinson's Disease during Optical Deep Brain Stimulation in Mouse Model
- 송강일; 박성희; 추준욱; 서준교; 최귀원; 황도식; 윤인찬
- Optogenetic; Parkinson’s disease; Deep
- Issue Date
- International BioMedical Engineering Conference 2014 (IBEC 2014)
- , NO POT2-38
- Deep brain stimulation (DBS) of subthalamic nucleus (STN) is recognized as a therapeutic option for progressive neurological disorders such as Parkinson’s disease. Even though the DBS has shown therapeutic effect, the underlying mechanism is still unclear. By using the optogenetic stimulation technology, it is possible to stimulate specific region and directly observe firing patterns during stimulation. In this study we investigated the effect of the optical DBS through the electrophysiology and behavior in hemi-Parkinsonian mouse and its influence on motor cortex. The electrophysiological responses were shown during high frequency optical DBS and burst spike firing rate in hemi-Parkinsonian mice model was reduced and the rotation rate were reduced under apomorphine condition. Moreover, firing rate in motor cortex was influenced by STN during optical stimulation in Parkinsonian model.
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