Synthesis and biological evaluation of chalcone analogues as protective agents against cisplatin-induced cytotoxicity in kideny cells

Title
Synthesis and biological evaluation of chalcone analogues as protective agents against cisplatin-induced cytotoxicity in kideny cells
Authors
Dahae LeeKi Hyun Kim문성원Heesu LeeKi Sung Kang이재욱
Keywords
chalcone; cisplatin-induced nephrotoxicity; renoprotection; MAPKs-p53-caspase3
Issue Date
2015-05
Publisher
Bioorganic & medicinal chemistry letters
Citation
VOL 25, NO 9, 1929-1932
Abstract
Chalcone analogues were prepared and evaluated for any renoprotective effects on cisplatin-treated cultured kidney cells (LLC-PK1); two chalcone analogues exhibited a potent renoprotective effect. In an additional study, we demonstrated that the blocking of MAPKs-p53-caspase-3 signaling cascade plays an important role in mediating the protective effect of these compounds against oxidative cytotoxicity in cultured LLC-PK1 cells.
URI
http://pubs.kist.re.kr/handle/201004/49589
ISSN
0960894X
Appears in Collections:
KIST Publication > Article
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