Real-time imaging of glioblastoma using bioluminescence in a U-87 MG xenograft model mouse
- Real-time imaging of glioblastoma using bioluminescence in a U-87 MG xenograft model mouse
- 김웅; 강보람; 김혜연; 조수민; 이용덕; 김세훈; 김정영; 김동진; 김영수
- Bioluminescence imaging; Glioblastoma; U-
87 MG; Xenograft
- Issue Date
- 한국응용생명화학회지; JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY
- VOL 58, NO 2, 243-248
- Glioblastoma multiforme (GBM), the most common malignant brain tumor, is characterized by
aggressive proliferation and invasive potential. Xenograft animal models of GBM have critically contributed to evaluation of novel therapeutic agents, drug delivery system, and diagnostic tools. To mimic intrinsic behavior of GBM, orthotopic transplantation of cancer cells and continuous observation of cell growth should be conducted in animal study. Here, we generated xenograft model mouse of GBM in which U-87 MG human glioblastoma cells were intracranially implanted for live imaging. Introducing luciferase gene into U-87 MG cell line enabled real-time observation and quantification of tumor survival and propagation by detecting photon emission derived from luciferase. Our GBM model mouse has potentials to bring great advantages in pharmacological and mechanistic investigation on brain tumors.
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