Real-time imaging of glioblastoma using bioluminescence in a U-87 MG xenograft model mouse

Title
Real-time imaging of glioblastoma using bioluminescence in a U-87 MG xenograft model mouse
Authors
김웅강보람김혜연조수민이용덕김세훈김정영김동진김영수
Keywords
Bioluminescence imaging; Glioblastoma; U- 87 MG; Xenograft
Issue Date
2015-04
Publisher
한국응용생명화학회지; JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY
Citation
VOL 58, NO 2, 243-248
Abstract
Glioblastoma multiforme (GBM), the most common malignant brain tumor, is characterized by aggressive proliferation and invasive potential. Xenograft animal models of GBM have critically contributed to evaluation of novel therapeutic agents, drug delivery system, and diagnostic tools. To mimic intrinsic behavior of GBM, orthotopic transplantation of cancer cells and continuous observation of cell growth should be conducted in animal study. Here, we generated xenograft model mouse of GBM in which U-87 MG human glioblastoma cells were intracranially implanted for live imaging. Introducing luciferase gene into U-87 MG cell line enabled real-time observation and quantification of tumor survival and propagation by detecting photon emission derived from luciferase. Our GBM model mouse has potentials to bring great advantages in pharmacological and mechanistic investigation on brain tumors.
URI
http://pubs.kist.re.kr/handle/201004/50049
ISSN
17382203
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KIST Publication > Article
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