Synthesis of (2-amino)ethyl derivatives of quercetin 3-O-methyl ether and their antioxidant and neuroprotective effects

Title
Synthesis of (2-amino)ethyl derivatives of quercetin 3-O-methyl ether and their antioxidant and neuroprotective effects
Authors
Young Hun Lee김형자Ho YooSeo Yun JungBong Jin KwonNam-Jung Kim진창배Yong Sup Lee
Keywords
Quercetin 3-O-methyl ether; Aminoethyl; Antioxidant; Neuroprotection; MCAO model
Issue Date
2015-08
Publisher
Bioorganic & medicinal chemistry
Citation
VOL 23, NO 15, 4970-4979
Abstract
Reactive oxygen species have been implicated in several diseases, particularly in ischemia-reperfusion injury. Quercetin 3-O-methyl ether has been reported to show potent antioxidant and neuroprotective activity against neuronal damage induced by reactive oxygen species. Several aminoethyl-substituted derivatives of quercetin 3-O-methyl ether have been synthesized to increase water solubility while retaining antioxidant and neuroprotective activity. Among such derivatives, compound 3a shows potent and well-balanced antioxidant activity in three types of cell-free assay systems and has in vivo neuroprotective effects on transient focal ischemic injury induced by the occlusion of the middle cerebral artery in rats.
URI
http://pubs.kist.re.kr/handle/201004/50105
ISSN
09680896
Appears in Collections:
KIST Publication > Article
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