Effect of Lycoris chejuensis and its active components on experimental models of Alzheimer's disease

Title
Effect of Lycoris chejuensis and its active components on experimental models of Alzheimer's disease
Authors
김준기박유림천윤선차진욱권학철오명숙정성권양현옥
Keywords
Lycoris chejuensis; narciclasine; Alzheimer's disease; Neurodegenerative disease; Brain; Natural product; Amyloid beta; Amyloid precursor protein
Issue Date
2015-07
Publisher
Journal of agricultural and food chemistry
Citation
VOL 63, NO 31, 6979-6988
Abstract
We found that an extract of Lycoris chejuensis and its three isolated active components, narciclasine, 7-deoxynarciclasine, and 7-deoxy-trans-dihydronarciclasine, each significantly reduce d the formation of amyloid-β peptides in HeLa cells transfected with an amyloid precursor protein carrying the Swedish mutation up to 45 ± .6%. The extract down-regulated amyloid precursor protein, especially the mature form by up to 88%, and reduced the ability of secretases to generate toxic amyloid-β. Double-transgenic mice treated with the extract for 4 months also showed significantly reduced levels of amyloid-β and plaques while exhibiting improved memory functions in the Morris water maze and novel object recognition tests. In conclusion, the extract and isolated active components of L. chejuensis decreased the production of amyloid-β by attenuating amyloid precursor protein levels. Furthermore, the extract improved the disrupted memory functions in animals while inhibiting amyloid plaque formation. Thus, this extract, as well as its active components, could prove beneficial in the treatment of Alzheimer’s disease.
URI
http://pubs.kist.re.kr/handle/201004/50142
ISSN
00218561
Appears in Collections:
KIST Publication > Article
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