Inhibitory Effects of Sphallerocarpus gracilis on IgE-induced Degranulation in Rat Basophilic Leukemia Mast Cells and TNF-α- and IFN-γ-induced Expression of Chemokines and Cytokines in Human Keratinocytes

Title
Inhibitory Effects of Sphallerocarpus gracilis on IgE-induced Degranulation in Rat Basophilic Leukemia Mast Cells and TNF-α- and IFN-γ-induced Expression of Chemokines and Cytokines in Human Keratinocytes
Authors
김명석남의정아흐마드 란디임수지노주원
Keywords
Sphallerocarpus gracilis; IgE; Keratinocytes; Chemokines
Issue Date
2015-08
Publisher
2015년도 한국응용생명화학회 국제학술대회
Abstract
Sphallerocarpus gracilis from Mongol is a little-investigated edible and medicinal plant. In the present study, the effects of Sphallerocarpus gracilis extract (SGE) on activation and degranulation of rat basophilic leukemia (RBL-2H3) mast cells and expression of chemokines and cytokines in HaCaT cells were investigated. To evaluate the effects of SGE on allergy and atopic dermatitis, we determined its effects on degranulation, and inflammatory mediators in IgE-stimulated RBL-2H3 cells and production and expression of chemokines and cytokines in TNF-α- and IFN-γ-stimulated HaCaT cells. SGE inhibited secretion of β-hexosaminidase and histamine, production of prostaglandin E2, and the mRNA expression of IL-4, and TNF-α in -stimulated RBL-2H3 cells. Furthermore, SGE also inhibited productions and expressions of TARC, MDC, and IL-6 in TNF-α- and IFN-γ-stimulated HaCaT cells. These results indicate that SGE might be useful as an agent against immediate-type hypersensitivity and atopic dermatitis.
URI
http://pubs.kist.re.kr/handle/201004/50150
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KIST Publication > Conference Paper
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