Discrete Pattern of Burst Stimulation in the Ventrobasal Thalamus for Anti-Nociception

Title
Discrete Pattern of Burst Stimulation in the Ventrobasal Thalamus for Anti-Nociception
Authors
허여울조제원
Keywords
Deep brain stimulation; Ventrobasal thalamus; Anti-nociception; Burst stimulation
Issue Date
2013-06
Publisher
PLoS ONE
Citation
VOL 8, NO 6, e67655-1-e67655-10
Abstract
The thalamus has been proposed to play a role in sensory modulation via switching between tonic and burst dual firing of individual neurons. Of the two firing modes, altered burst firing has been repeatedly implicated with pathological pain conditions, which suggests that maintaining a certain form of thalamic burst could be crucial for controlling pain. However, specific elements of burst firing that may contribute to pain control have not yet been actively investigated. Utilizing the deep brain stimulation (DBS) technique, we explored the effects of bursting properties in pain control by electrically stimulating the ventrobasal (VB) thalamus in forms of burst patterned to test different aspects of bursts during the formalin induced nociception in mice. Our results demonstrated that electrical stimulations mimicking specific burst firing properties are important in producing an anti-nociceptive effect and found that the ≤3 ms interval between burst pluses (intra-burst-interval: IntraBI) and ≥3 pulses per burst were required to reliably reduce formalin induced nociceptive responses in mice. Periodicity of IntraBI was also suggested to contribute to anti-nociception to a limited extent.
URI
http://pubs.kist.re.kr/handle/201004/50174
ISSN
19326203
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE