Structured synaptic connectivity between hippocampal regions
- Structured synaptic connectivity between hippocampal regions
- Shaul Druckmann; 린칭; 이보경; 육채현; Ting Zhao; Jeffrey C. Magee; 김진현
- Issue Date
- VOL 81, NO 3, 629-640
- The organization of synaptic connectivity within a
neuronal circuit is a prime determinant of circuit
function. We performed a comprehensive fine-scale
circuit mapping of hippocampal regions (CA3-CA1)
using the newly developed synapse labeling method,
mGRASP. This mapping revealed spatially nonuniform
and clustered synaptic connectivity patterns.
Furthermore, synaptic clustering was enhanced
between groups of neurons that shared a similar
developmental/migration time window, suggesting
a mechanism for establishing the spatial structure
of synaptic connectivity. Such connectivity patterns
are thought to effectively engage active dendritic
processing and storage mechanisms, thereby potentially
enhancing neuronal feature selectivity.
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