A physical association between the human mutY homolog (hMYH) and DNA topoisomerase II-binding protein 1 (hTopBP1) regulates Chk1-induced cell cycle arrest in HEK293 cells

Title
A physical association between the human mutY homolog (hMYH) and DNA topoisomerase II-binding protein 1 (hTopBP1) regulates Chk1-induced cell cycle arrest in HEK293 cells
Authors
한세희Soo-Hyun HahmAn Hue Vy TranJi Hyung ChungMyoung-Ki HongHyun-Dong Paik김기선Ye Sun Han
Keywords
Human topoisomerase II-binding protein 1 (hTopBP1); Human mutY homolog (hMYH); Human Rad9; Phospho-Chk1; Cell cycle arrest; ATR signaling
Issue Date
2015-08
Publisher
Cell and Bioscience
Citation
VOL 5, NO 50, 1-11
Abstract
Human DNA topoisomerase II-binding protein 1 (hTopBP1) plays an important role in DNA replication and the DNA damage checkpoint pathway. The human mutY homolog (hMYH) is a base excision repair DNA glycosylase that excises adenines or 2-hydroxyadenines that are mispaired with guanine or 7,8-dihydro-8-oxoguanine (8-oxoG). hTopBP1 and hMYH were involved in ATR-mediated Chk1 activation, moreover, both of them were associated with ATR and hRad9 which known as checkpoint-involved proteins. Therefore, we investigated whether hTopBP1 interacted with hMYH, and what the function of their interaction is.
URI
http://pubs.kist.re.kr/handle/201004/50229
ISSN
20453701
Appears in Collections:
KIST Publication > Article
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