A small-molecule probe for selective profiling and imaging of monoamine oxidase B activities in models of parkinson's disease

Title
A small-molecule probe for selective profiling and imaging of monoamine oxidase B activities in models of parkinson's disease
Authors
Li linZhang Cheng-WuGe JingyanQian LinghuiChai Bing-HanZhu Qing이준석Lim Kah-LeongYao, Shao Q.
Issue Date
2015-09
Publisher
Angewandte Chemie international edition
Citation
VOL 54, NO 37, 10821-10825
Abstract
The design of the first dual-purpose activity-based probe of monoamine oxidaseB (MAO-B) is reported. This probe is highly selective towardsMAO-B, even at highMAO-A expression levels, and could sensitively report endogenous MAO-B activities by both in situ proteome profiling and livecell bioimaging. With a built-in imaging module as part of the probe design, the probe was able to accomplish what all previously reported MAO-B imaging probes failed to do thus far: the live-cell imaging of MAO-B activities without encountering diffusion problems.
URI
http://pubs.kist.re.kr/handle/201004/50230
ISSN
14337851
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE