Dependence of impedance measurement sensitivity of cell growth on sensing area of circular interdigitated electrode

Title
Dependence of impedance measurement sensitivity of cell growth on sensing area of circular interdigitated electrode
Authors
박진수황교선조성보
Keywords
Equivalent Circuit; Electrochemical Impedance Spectroscopy; Cellular Biosensor; Label-Free Detection
Issue Date
2015-10
Publisher
Journal of nanoscience and nanotechnology
Citation
VOL 15, NO 10, 7886-7890
Abstract
A circular interdigitated electrode (IDE) array for label-free and real-time impedance monitoring of cell growth was fabricated and evaluated. Both the width and spacing of fingers were 50 m, and the exposed sensing area of the circular IDE was 1.3∼3.4 mm. The electrical characteristics of the fabricated circular IDE were modeled as an equivalent circuit, and the values of the circuit parameters extrapolated from the fitting to the measured spectra in different concentrations of NaCl or sensing areas of the circular IDE were analyzed. During cell growth, the resistance of cells extrapolated from the fitting was increased and the maximum rate of change in the real part of the impedance was observed at frequencies of 10 to 22 kHz. The normalized real part of the impedance measured at 10 kHz during cell growth was increased more with decreasing the electrode sensing area, albeit the number of cells to be investigated showed a corresponding increase.
URI
http://pubs.kist.re.kr/handle/201004/50290
ISSN
15334880
Appears in Collections:
KIST Publication > Article
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