Physiological functions of the TRPM4 channels via protein interactions

Title
Physiological functions of the TRPM4 channels via protein interactions
Authors
조장훈이영선김은주황은미박재용
Keywords
TRPM4; Glycosylation,; Heteromerization,; Phosphorylation,; SUMOylation,; Trafficking,; 14-3-3γ
Issue Date
2015-01
Publisher
BMB REPORTS
Citation
VOL 48, NO 1, 1-5
Abstract
Transient Receptor Potential, Melastatin-related, member 4 (TRPM4) channels are Ca2+-activated Ca2+-impermeable cation channels. These channels are expressed in various types of mammalian tissues including the brain and are implicated in many diverse physiological and pathophysiological conditions. In the past several years, the trafficking processes and regulatory mechanism of these channels and their interacting proteins have been uncovered. Here in this minireview, we summarize the current understanding of the trafficking mechanism of TRPM4 channels on the plasma membrane as well as heteromeric complex formation via protein interactions. We also describe physiological implications of protein-TRPM4 interactions and suggest TRPM4 channels as therapeutic targets in many related diseases. [BMB Reports 2015; 48(1): 1-5]
URI
http://pubs.kist.re.kr/handle/201004/50337
ISSN
19766696
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KIST Publication > Article
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