Physiological functions of the TRPM4 channels via protein interactions
- Physiological functions of the TRPM4 channels via protein interactions
- 조장훈; 이영선; 김은주; 황은미; 박재용
- TRPM4; Glycosylation,; Heteromerization,; Phosphorylation,; SUMOylation,; Trafficking,; 14-3-3γ
- Issue Date
- BMB REPORTS
- VOL 48, NO 1, 1-5
- Transient Receptor Potential, Melastatin-related, member 4 (TRPM4) channels are Ca2+-activated Ca2+-impermeable cation channels. These channels are expressed in various types of
mammalian tissues including the brain and are implicated in many diverse physiological and pathophysiological conditions. In the past several years, the trafficking processes and regulatory mechanism of these channels and their interacting proteins have been uncovered. Here in this minireview, we summarize the current understanding of the trafficking mechanism of TRPM4 channels on the plasma membrane as well as heteromeric complex formation via protein interactions. We also describe physiological implications of protein-TRPM4 interactions and suggest TRPM4 channels as therapeutic targets in many related diseases. [BMB Reports 2015; 48(1): 1-5]
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