Blood-compatible bio-inspired surface of poly (L-lactide-co-ε-caprolactone) films prepared using poor co-solvent casting

Title
Blood-compatible bio-inspired surface of poly (L-lactide-co-ε-caprolactone) films prepared using poor co-solvent casting
Authors
임진익김수현
Issue Date
2015-05
Publisher
폴리머; Polymer(Korea)
Citation
VOL 39, NO 1, 40-45
Abstract
혈항혈전성 표면의 제조를 위해 간단한 비용매 휘발 방법을 통하여 고탄성체이면서 생분해성 폴리 락티드-카프로락톤 공중합체 필름의 표면상에 연잎 구조물과 유사한 마이크로 돌기를 만들어 주었다. 표면 구조와 소수성도, 항혈전 효과 등을 시험했으며, 결정화도와 탄성회복률 등의 물리적 특성도 분석하였다. 그 결과 비용매와 메틸렌클 로라이드의 혼합 부피비 1:2에서 연잎표면과 유사한 최적의 효과를 얻었으며, 이때 수접촉각은 124o였다. 혈소판 부 착시험에서는 처리하지 않는 군에 비해 약 10%만 부착되는 효과를 확인할 수 있었다. Simple poor-cosolvent casting was used to surface treat biodegradable elastic poly(L-lactide-co-ε-caprolactone) (PLCL; 50:50) copolymer films that presented lotus-leaf-like structures. We evaluated whether the lotus-leaflike-structured PLCL (L-PLCL) films could be used as a biomaterial for artificial vascular grafts. The surface morphology, hydrophobicity, and antithrombotic efficiency of the films were examined while immersed in platelet-rich plasma (PRP) using scanning electron microscopy (SEM) and a contact angle meter. The recovery and crystallinity of the films were measured using a tensile-strength testing machine and an X-ray diffractometer, respectively. The solvent containing acetic acid, as a poor co-solvent, and methylene chloride mixed in a 1:2 ratio produced an optimal PLCL film with a water contact angle of approximately 124o. Furthermore, the surface of the L-PLCL films immersed in PRP showed a lower rate of platelet adhesion (<10%) than that of the surface of an untreated PLCL film immersed in PRP.
URI
http://pubs.kist.re.kr/handle/201004/50388
ISSN
0379153X
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KIST Publication > Article
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