A novel tissue-engineered trachea with a mechanical behavior similar to native trachea

Title
A novel tissue-engineered trachea with a mechanical behavior similar to native trachea
Authors
박정훈홍정민주영민정진우강현욱이상진유지김성원김수현조동우
Keywords
Indirect 3D printing; Bellows scaffold; Heparinization; Tracheal cartilage regeneration; Appropriate mechanical behavior
Issue Date
2015-09
Publisher
Biomaterials
Citation
VOL 62, 106-115
Abstract
A novel tissue-engineered trachea was developed with appropriate mechanical behavior and substantial regeneration of tracheal cartilage. We designed hollow bellows scaffold as a framework of a tissue-engineered trachea and demonstrated a reliable method for three-dimensional (3D) printing of monolithic bellows scaffold. We also functionalized gelatin sponge to allow sustained release of TGF-beta 1 for stimulating tracheal cartilage regeneration and confirmed that functionalized gelatin sponge induces cartilaginous tissue formation in vitro. A tissue-engineered trachea was then created by assembling chondrocytes-seeded functionalized gelatin sponges into the grooves of bellows scaffold and it showed very similar mechanical behavior to that of native trachea along with substantial regeneration of tracheal cartilage in vivo. The tissue-engineered trachea developed here represents a novel concept of tracheal substitute with appropriate mechanical behavior similar to native trachea for use in reconstruction of tracheal stenosis
URI
http://pubs.kist.re.kr/handle/201004/50390
ISSN
01429612
Appears in Collections:
KIST Publication > Article
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