Synthesis of Novel Dihydropyridothienopyrimidin-4,9-dione Derivatives

Title
Synthesis of Novel Dihydropyridothienopyrimidin-4,9-dione Derivatives
Authors
김영재김민주박무성태진성백두종박기덕추현아
Keywords
dihydropyridothienopyrimidin-4,9-dione; pyridothienopyrimidine; successive ring formation
Issue Date
2015-03
Publisher
Molecules
Citation
VOL 20, 5074-5084
Abstract
A novel molecular scaffold, dihydropyridothienopyrimidin-4,9-dione, was synthesized from benzylamine or p-methoxybenzylamine in six steps involving successive ring closure to form a fused ring system composed of dihydropyridone, thiophene and pyrimidone. The pharmacological versatility of the dihydropyridothenopyrimidin-4,9-dione scaffold was demonstrated by inhibitory activity against metabotropic glutamate receptor subtype 1 (mGluR1), which shows that the title compounds can serve as an interesting scaffold for the discovery of potential bioactive molecules for the treatment of human diseases.
URI
http://pubs.kist.re.kr/handle/201004/50398
ISSN
14203049
Appears in Collections:
KIST Publication > Article
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