Functional nerve cuff electrode with controllable anti-inflammatory drug loading and release by biodegradable nanofibers and hydrogel deposition

Title
Functional nerve cuff electrode with controllable anti-inflammatory drug loading and release by biodegradable nanofibers and hydrogel deposition
Authors
박성진이이재허동녕권일근윤광석강지윤이수현
Keywords
Nerve cuff electrode; Drug loading control; Controlled drug release; Nanofiber; Hydrogel; conductive polymer
Issue Date
2015-08
Publisher
Sensors and actuators. B, Chemical
Citation
VOL 215, 133-141
Abstract
tThis paper demonstrates a polyimide nerve cuff electrode with a controllable drug loading/release func-tion for stable recording of peripheral nerve signals and stimulation and minimizing inflammation. Forcontrol of anti-inflammatory drug loading/release, dexamethasone (DEX)-loaded poly L-lactic acid (PLLA)and/or poly lactic-co-glycol acid (PLGA) nanofibers were deposited on a functional nerve cuff electrodeby the electro-spinning method, which can control the weight of DEX loading on the functional nervecuff electrode. Then, UV patternable polyethylene glycol (PEG) was coated on the functional nerve cuffwith DEX-loaded nanofibers for the acceleration of the release rate of the drug. Through high perfor-mance liquid chromatography (HPLC), DEX release rates were increased from 16 to 28% (PLLA-loadednanofibers) and from 68 to 87% (PLGA-loaded nanofibers) due to the increased diffusion rate of DEXafter 28 days, respectively. In addition, the functional nerve cuff electrode was electro-polymerized withpoly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) as a conductive polymer in orderto recover the decreased electrical properties caused by PEG patterning. The impedance measured at1 kHz was 342 mm2, which was extremely lower than the value of 1046 mm2of PEG-patterned cuffelectrodes. Through the acute ex-vivo test of SD rat’s sciatic nerve, the functional nerve cuff electrodewith PEDOT:PSS exhibited stable and effective recording of the nerve’s signals despite PEG patterning.
URI
http://pubs.kist.re.kr/handle/201004/50400
ISSN
09254005
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KIST Publication > Article
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