Functional nerve cuff electrode with controllable anti-inflammatory drug loading and release by biodegradable nanofibers and hydrogel deposition
- Functional nerve cuff electrode with controllable anti-inflammatory drug loading and release by biodegradable nanofibers and hydrogel deposition
- 박성진; 이이재; 허동녕; 권일근; 윤광석; 강지윤; 이수현
- Nerve cuff electrode; Drug loading control; Controlled drug release; Nanofiber; Hydrogel; conductive polymer
- Issue Date
- Sensors and actuators. B, Chemical
- VOL 215, 133-141
- tThis paper demonstrates a polyimide nerve cuff electrode with a controllable drug loading/release func-tion for stable recording of peripheral nerve signals and stimulation and minimizing inflammation. Forcontrol of anti-inflammatory drug loading/release, dexamethasone (DEX)-loaded poly L-lactic acid (PLLA)and/or poly lactic-co-glycol acid (PLGA) nanofibers were deposited on a functional nerve cuff electrodeby the electro-spinning method, which can control the weight of DEX loading on the functional nervecuff electrode. Then, UV patternable polyethylene glycol (PEG) was coated on the functional nerve cuffwith DEX-loaded nanofibers for the acceleration of the release rate of the drug. Through high perfor-mance liquid chromatography (HPLC), DEX release rates were increased from 16 to 28% (PLLA-loadednanofibers) and from 68 to 87% (PLGA-loaded nanofibers) due to the increased diffusion rate of DEXafter 28 days, respectively. In addition, the functional nerve cuff electrode was electro-polymerized withpoly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) as a conductive polymer in orderto recover the decreased electrical properties caused by PEG patterning. The impedance measured at1 kHz was 342 mm2, which was extremely lower than the value of 1046 mm2of PEG-patterned cuffelectrodes. Through the acute ex-vivo test of SD rat’s sciatic nerve, the functional nerve cuff electrodewith PEDOT:PSS exhibited stable and effective recording of the nerve’s signals despite PEG patterning.
- Appears in Collections:
- KIST Publication > Article
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.