Biofunctionalized Ceramic with Self-Assembled Networks of Nanochannel

Title
Biofunctionalized Ceramic with Self-Assembled Networks of Nanochannel
Authors
장해린이근호강찬순이혜경안효용정희윤박승학김슬참진경석박지민양태열김진홍신선애한흥남오규환이호영임준홍국선말콤 스니드지미 슈남기태
Keywords
nanochannels; hierarchical structures; bioinspired; fluid transports; ceramics; pressure gradient sintering; polymer agglomeration
Issue Date
2015-04
Publisher
ACS Nano
Citation
VOL 9, NO 4447, 4447-4457
Abstract
Nature designs circulatory systems with hierarchically organized networks of gradually tapered channels ranging from micrometer to nanometer in diameter. In most hard tissues in biological systems, fluid, gases, nutrients and wastes are constantly exchanged through such networks. Here, we developed a biologically inspired, hierarchically organized structure in ceramic to achieve effective permeation with minimum void region, using fabrication methods that create a long-range, highly interconnected nanochannel system in a ceramic biomaterial. This design of a synthetic model-material was implemented through a novel pressurized sintering process formulated to induce a gradual tapering in channel diameter based on pressure-dependent polymer agglomeration. The resulting system allows long-range, efficient transport of fluid and nutrients into sites and interfaces that conventional fluid conduction cannot reach without external force. We demonstrate the ability of mammalian bone-forming cells placed at the distal transport termination of the nanochannel system to proliferate in a manner dependent solely upon the supply of media by the self-powering nanochannels. This approach mimics the significant contribution that nanochannel transport plays in maintaining living hard tissues by providing nutrient supply that facilitates cell growth and differentiation, and thereby makes the ceramic composite “alive”.
URI
http://pubs.kist.re.kr/handle/201004/50452
ISSN
19360851
Appears in Collections:
KIST Publication > Article
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