Design of a platform technology for systemic delivery of siRNA to tumours using rolling circle transcription
- Design of a platform technology for systemic delivery of siRNA to tumours using rolling circle transcription
- 장미희; 김종환; 남혜윤; 권익찬; 안형준
- siRNA; delivery carrier; RNA nanoparticle; cancer therapy
- Issue Date
- Nature Communications
- VOL 6, 7930-1-7930-12
- For therapeutic applications of siRNA, there are technical challenges with respect to targeted
and systemic delivery. We here report a new siRNA carrier, RNAtr NPs, in a way that multiple
tandem copies of RNA hairpins as a result of rolling circle transcription (RCT) can be readily
adapted in tumour-targeted and systemic siRNA delivery. RNAtr NPs provide a means of condensing large amounts of multimeric RNA transcripts into the compact nanoparticles, especially without the aid of polycationic agents, and thus reduce the risk of immunogenicity and cytotoxicity by avoiding the use of synthetic polycationic reagents. This strategy allows the design of a platform technology for systemic delivery of siRNA to tumour sites, because RCT reaction, which enzymatically generates RNA polymers in multiple copy numbers at low cost, can lead to directly accessible routes to targeted and systemic delivery. Therefore, RNAtr NPs suggest great potentials as the siRNA therapeutics for cancer treatment.
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