Design of a platform technology for systemic delivery of siRNA to tumours using rolling circle transcription

Title
Design of a platform technology for systemic delivery of siRNA to tumours using rolling circle transcription
Authors
장미희김종환남혜윤권익찬안형준
Keywords
siRNA; delivery carrier; RNA nanoparticle; cancer therapy
Issue Date
2015-08
Publisher
Nature Communications
Citation
VOL 6, 7930-1-7930-12
Abstract
For therapeutic applications of siRNA, there are technical challenges with respect to targeted and systemic delivery. We here report a new siRNA carrier, RNAtr NPs, in a way that multiple tandem copies of RNA hairpins as a result of rolling circle transcription (RCT) can be readily adapted in tumour-targeted and systemic siRNA delivery. RNAtr NPs provide a means of condensing large amounts of multimeric RNA transcripts into the compact nanoparticles, especially without the aid of polycationic agents, and thus reduce the risk of immunogenicity and cytotoxicity by avoiding the use of synthetic polycationic reagents. This strategy allows the design of a platform technology for systemic delivery of siRNA to tumour sites, because RCT reaction, which enzymatically generates RNA polymers in multiple copy numbers at low cost, can lead to directly accessible routes to targeted and systemic delivery. Therefore, RNAtr NPs suggest great potentials as the siRNA therapeutics for cancer treatment.
URI
http://pubs.kist.re.kr/handle/201004/50482
ISSN
20411723
Appears in Collections:
KIST Publication > Article
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