Heterogeneity of tremor mechanisms assessed by tremor-related cortical potential in mice
- Heterogeneity of tremor mechanisms assessed by tremor-related cortical potential in mice
- 박영균; 최지현; 이충기; 김세연; 김영수; 장기영; 백선아; 김대수
- Tremor mechanism; Cortical rhythm; Harmaline; T-type Ca2+ channels
- Issue Date
- Molecular Brain
- VOL 8
- Background: Identifying a neural circuit mechanism that is differentially involved in tremor would aid in the diagnosis and cure of such cases. Here, we demonstrate that tremor-related cortical potential (TRCP) is differentially expressed in two different mouse models of tremor.
Results: Hybrid tremor analysis of harmaline-induced and genetic tremor in mice revealed that two authentic tremor frequencies for each type of tremor were conserved and showed an opposite dependence on CaV3.1 T-type Ca2+ channels. Electroencephalogram recordings revealed that α1−/−;α1G-/- mice double-null for the GABA receptor α1 subunit (Gabra1) and CaV3.1 T-type Ca2+ channels (Cacna1g), in which the tremor caused by the absence of Gabra1 is potentiated by the absence of Cacna1g, showed a coherent TRCP that exhibited an onset that preceded the initiation of behavioral tremor by 3 ms. However, harmaline-induced tremor, which is known to be abolished by α1G−/−, showed no TRCP.
Conclusions: Our results demonstrate that the α1−/−;α1G−/− double-knockout tremor model is useful for studying cortical mechanisms of tremor.
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