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dc.contributor.author이소진-
dc.contributor.authorSimmyung Yook-
dc.contributor.authorJi Young Yhee-
dc.contributor.author윤홍열-
dc.contributor.author김명구-
dc.contributor.author구숙희-
dc.contributor.author김선화-
dc.contributor.authorJae Hyung Park-
dc.contributor.authorJi Hoon Jeong-
dc.contributor.author권익찬-
dc.contributor.authorSeulki Lee-
dc.contributor.authorHyukjin Lee-
dc.contributor.author김광명-
dc.date.accessioned2015-12-03T02:07:09Z-
dc.date.available2015-12-03T02:07:09Z-
dc.date.issued201508-
dc.identifier.citationVOL 게재예정, 게재예정-
dc.identifier.issn01683659-
dc.identifier.other45140-
dc.identifier.urihttp://pubs.kist.re.kr/handle/201004/50569-
dc.description.abstractCancer is a multifactorial disease which involves complex genetic mutation and dysregulation. Combinatorial RNAi technology and concurrent multiple gene silencing are expected to provide advanced strategies for effective cancer therapy, but a safe and effective carrier system is a prerequisite to successful siRNA delivery in vivo. We previously developed an effective tumor-targeting siRNA delivery system for in vivo application. In response to the success of this development, herein we present a dual-gene targeted siRNA and its delivery system, to achieve synergistic effects in cancer therapy. Two different sequences of siRNA were chemically modified to be randomly copolymerized in a single backbone of siRNA polymer (Dual-poly-siRNA), and the resulting Dual-poly-siRNA was incorporated into tumor-homing glycol chitosan nanoparticles. Based on the stability in serum and delivery in a tumor-targeted manner, intravenously administered Dual-poly-siRNA carrying glycol chitosan nanoparticles (Dual-NP) demonstrated successful dual-gene silencing in tumors. Notably, co-delivery of VEGF and Bcl-2 targeting siRNA led to more effective cancer therapy for convenient application-
dc.publisherJournal of controlled release-
dc.subjectDual-gene delivery-
dc.subjectGlycol chitosan-
dc.subjectNanoparticle-
dc.subjectTumor targeted delivery-
dc.subjectsiRNA polymer-
dc.titleCo-delivery of VEGF and Bcl-2 dual-targeted siRNA polymer using a single nanoparticle for synergistic anti-cancer effects in vivo-
dc.typeArticle-
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