Nanoparticle-Based Combination Therapy for Cancer Treatment

Title
Nanoparticle-Based Combination Therapy for Cancer Treatment
Authors
이지영손세진Hyukjin Lee김광명
Keywords
Cancer; combination therapy; nanoparticle; targeted drug delivery
Issue Date
2015-07
Publisher
Current pharmaceutical design
Citation
VOL 21, NO 22, 3158-3166
Abstract
In recent years, combination of different types of therapies using nanoparticles has emerged as an advanced strategy for cancer treatment. Most of all, combination of chemotherapeutic drug and siRNA in nanoformulation has shown a great potential, because siRNA-mediated specific gene silencing can compensate for the incomplete anti-cancer actions of chemotherapy. In this article, nanoparticle-based combination therapy for cancer treatment is introduced to be focused on the therapeutic chemical and siRNA combination. It is classified into 3 groups: 1) general chemotherapy combined with siRNA carrying nanoparticle, 2) co-delivery of chemical and siRNA therapeutics within a single nanoparticle, and 3) Use of multiple nanoparticles for chemical and siRNA therapeutics. The purpose of the combination and the mechanisms of anti-cancer action was described according to the categories. Examples of some recent developments of nanotechnology-based chemo- and siRNA- therapeutics combination therapy are summarized for better understanding of its practical application.
URI
http://pubs.kist.re.kr/handle/201004/50598
ISSN
13816128
Appears in Collections:
KIST Publication > Article
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