Experimental autoimmune encephalomyelitis and age-related correlations of NADPH oxidase, MMP-9, and cell adhesion molecules: The increased disease severity and blood-brain barrier permeability in middle-aged mice.

Title
Experimental autoimmune encephalomyelitis and age-related correlations of NADPH oxidase, MMP-9, and cell adhesion molecules: The increased disease severity and blood-brain barrier permeability in middle-aged mice.
Authors
서지은마흐법하산한준승강민정정병화곽승기김호연권오승
Keywords
Experimental autoimmune encephalomyelitis; Age; Blood?brain barrier; NADPH oxidase; MMP-9; Adhesion molecules
Issue Date
2015-10
Publisher
Journal of neuroimmunology
Citation
VOL 287, 43-53
Abstract
The aimof the present studywas to investigate effect of two different ages (6weeks [6 W] vs. 6 months [6M]) on blood–brain barrier (BBB) disruption in EAE and evaluate the expression and correlations of NADPH oxidase, MMP-9, ICAM-1, and VCAM-1 following increased age and EAE induction. Higher disease severity was observed in 6M-EAE than 6W-EAE. The four factorswere significantly elevated and correlated in 6M-EAE. BBB permeability increased with statistically significant interaction between age and EAE effects.We suggest strong correlations between NADPH oxidase and the other factors play important roles in increased BBB disruption and EAE susceptibility in middle-aged mice
URI
http://pubs.kist.re.kr/handle/201004/50641
ISSN
01655728
Appears in Collections:
KIST Publication > Article
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