Amorphastilbol exerts beneficial effects on glucose and lipid metabolism in mice consuming a high-fat-diet.

Title
Amorphastilbol exerts beneficial effects on glucose and lipid metabolism in mice consuming a high-fat-diet.
Authors
Lee, Woojung함정엽권학철윤구배규운김용기김수남
Keywords
Amorpha fruticosa; amorphastilbol; PPAR a/r dual agonist; PTP1B; Insulin resistance
Issue Date
2015-08
Publisher
International journal of molecular medicine
Citation
VOL 36, NO 2, 527-533
Abstract
In the present study, the anti-diabetic effects of amorphastilbol (APH) from Amorpha fruticosa (AF) were evaluated in high-fat-diet (HFD) mice. HFD-induced blood glucose and insulin levels are significantly reduced in AF extract or APH treatment groups. HFD-induced weight gain was reduced by AF treatment, which is accompanied by reduction of fat mass and adipocyte size and number in white adipose tissues. Furthermore, total cholesterol and low-density lipoprotein-cholesterol levels are decreased in AF- or APH-treated mice. In addition, AF and APH are able to improve insulin sensitivity through inhibition of protein tyrosine phosphatase 1B, a negative regulator of the insulin-signaling pathway. Taken together, the data suggest that AF has beneficial effects on glucose and lipid metabolism and its pharmacological effects are driven, in part, by its active component, APH. Therefore, AF and APH can be used as potential therapeutic agents against type 2 diabetes and associated metabolic disorders, including obesity, by enhancing glucose and lipid metabolism.
URI
http://pubs.kist.re.kr/handle/201004/50735
ISSN
11073756
Appears in Collections:
KIST Publication > Article
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