Ligularia fischeriimproves diet-induced obesity-related metabolic dysfunctions by activating AMP-activated protein kinase and regulating lipid metabolism
- Ligularia fischeriimproves diet-induced obesity-related metabolic dysfunctions by activating AMP-activated protein kinase and regulating lipid metabolism
- 아흐마드 란디; 김명석; 노주원
- Ligularia fischeri; Obesity; AMPK; fatty liver; diabetes
- Issue Date
- The 6th International Conference on Food Factors
- Ligularia fischeri has been considered to possess health-improving benefit and used as an herbal
plant. Specifically, its leaves are used for to improve medicinal condition such as jaundice, scarlet fever, and hepatic function. The present study was aimed to investigate the protective effects of Ligularia fischeri extract (LFE) on hepatocyte in HepG2 cell model cultured with high fatty acid and its effect on obesity, and other metabolic disorder markers in high-fat induced-obesity mice model. On the HepG2 culture model, LFE reduces lipid accumulation and enhanced fatty acid oxidation, contributing to amelioration of lipid accumulation induced by high fatty acid. LFE also inhibited acetyl coenzyme-A carboxylase activities by stimulating adenosine monophosphate-activated protein kinase (AMPK). LFE attenuated the expression of sterol regulatory element-binding protein-1 and its target molecules, such as fatty acid synthase. In contrast, the expressions of lipolytic markers such as peroxisome proliferator activated receptor α and carnitine palmitoyltransferase-1 were increased. This study suggests the hypolipidemic effects of LFE occur via activation of AMPK pathway by phosphorylation of AMPK, and inhibition of lipid biosynthesis and stimulation of lipolysis. Furthermore isolated compounds from LFE also show the potency to induce AMPK pathway activation. Meanwhile, oral administration of LFE reduces total body weight, fat pad masses, and liver weight of HFD-fed mice. Therefore, the LFE and its compounds may actively prevent nonalcoholic fatty liver disease.
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