Abnormalities of plasma cytokines and spleen in senile APP/PS1/Tau transgenic mouse model

Title
Abnormalities of plasma cytokines and spleen in senile APP/PS1/Tau transgenic mouse model
Authors
양승훈김지윤이지수김영수
Keywords
Alzheimer; dementia; blood; 알츠하이머; 치매; 혈액진단
Issue Date
2015-10
Publisher
Scientific Reports
Citation
VOL 5, NO 15703, 1-9
Abstract
The blood-based diagnosis has a potential to provide an alternative approach for easy diagnosis of Alzheimer’s disease (AD) with less invasiveness and low-cost. However, present blood-based AD diagnosis mainly focuses on measuring the plasma Aβ level because no other biomarkers are found to possess evident transport mechanisms to pass the blood-brain barrier. In order to avoid diagnosing non-demented individuals with Aβ abnormality, finding additional biomarkers to supplement plasma Aβ is essential. In this study, we introduce potential neurodegenerative biomarkers for blood-based diagnosis. We observed severe splenomegaly and structural destruction in the spleen with significantly decreased B lymphocytes in senile APPswe, PS1M146V and TauP301L transgenic mice. We also found that inflammatory cytokines associated with splenic dysfunction were altered in the plasma of these mice. These findings suggest potential involvement of the splenic dysfunction in AD and the importance of biomarker level alterations in the plasma as putative diagnostic targets for AD.
URI
http://pubs.kist.re.kr/handle/201004/50805
ISSN
20452322
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE