Nanoparticle coating on the silane-modified surface of magnesium for local drug delivery and controlled corrosion

Title
Nanoparticle coating on the silane-modified surface of magnesium for local drug delivery and controlled corrosion
Authors
Won Seok LeeMin ParkMyung Hun KimChun Gwon ParkBeom Kang Huh석현광Young Bin Choy
Keywords
Coating; corrosion; drug delivery; electrophoretic deposition; magnesium; silane; nanoparticles
Issue Date
2015-10
Publisher
Journal of biomaterials applications
Citation
VOL 게재예정, 게재예정
Abstract
In this study, we proposed a potential method for the preparation of a magnesium-based medical device for local drug delivery and controlled corrosion. A magnesium surface was modified with 3-aminopropyltrimethoxy silane, and the resulting surface was then coated with drug-loaded nanoparticles made of poly (lactic-co-glycolic acid) via electrophoretic deposition. The drug-loaded nanoparticles (i.e., Tr_NP) exhibited a size of 250 ± 67 nm and a negative zeta potential of -20.9 ± 2.75 mV. The drug was released from the nanoparticles in a sustained manner for 21 days, and this did not change after their coating on the silane-modified magnesium. The silane-modified surface suppressed magnesium corrosion. When immersed in phosphate buffered saline at pH 7.4, the average rate of hydrogen gas generation was 0.41-0.45 ml/cm2/day, compared to 0.58-0.6 ml/cm2/day from a bare magnesium surface. This corrosion profile was not significantly changed after nanoparticle coating under the conditions employed in this work. The in vitro cell test revealed that the drug released from the coating was effective during the whole release period of 21 days, and both the silane-modified surface and carrier nanoparticles herein were not cytotoxic.
URI
http://pubs.kist.re.kr/handle/201004/50828
ISSN
08853282
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KIST Publication > Article
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