Method Validation for β-carbolines in Vegetables with LC-MS/MS and Confirmation by UPLC-QTOF MS
- Method Validation for β-carbolines in Vegetables with LC-MS/MS and Confirmation by UPLC-QTOF MS
- 황인주; 오민석; 김해솔; 추석; 박현미
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- β-carboline (norharman) and 2-methyl- β-carboline (harman) are kind of heterocyclic amines (HCAs) that are formed in protein-rich foods by the reaction of tryptophan with some aldehydes under oxidation condition. It has been well known that β-carbolines were proved to have a negative effect on mammalian tissues and organs in animal experiments. It may take a role as potential mutagen or co-mutagen. A method for determination of heterocyclic amines (HCAs) in vegetables and its processed foodstuffs was developed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) for total diet study. The pretreatment procedure included the antioxidant such as ascorbic acid to avoid the any possible artifact formation from tetrahydro - β – carboline – 3 - carboxylic acid.
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