Tyrosine-mediated two-dimensional peptide assembly and its role as a bio-inspired catalytic scaffold

Title
Tyrosine-mediated two-dimensional peptide assembly and its role as a bio-inspired catalytic scaffold
Authors
장형석이정호박용선김영오박지민양태열진경석이재훈박승학유재명정기웅신아름오인선권민경김용일조훈휘한흥남김양미장윤호백승렬남기태이윤식
Keywords
Tyrosine; Peptide film; Water faceting; Catalytic scaffold
Issue Date
2014-03
Publisher
Nature Communications
Citation
VOL 5, NO 3665
Abstract
In two-dimensional interfacial assemblies, there is an interplay between molecular ordering and interface geometry, which determines the final morphology and order of entire systems. Here we present the interfacial phenomenon of spontaneous facet formation in a water droplet driven by designed peptide assembly. The identified peptides can flatten the rounded top of a hemispherical droplet into a plane by forming a macroscopic two-dimensional crystal structure. Such ordering is driven by the folding geometry of the peptide, interactions of tyrosine and crosslinked stabilization by cysteine. We discover the key sequence motifs and folding structures and study their sequence-specific assembly. The well-ordered, densely packed, redox-active tyrosine units in the YYACAYY (H-Tyr-Tyr-Ala-Cys-Ala-Tyr-Tyr-OH) film can trigger or enhance chemical/electrochemical reactions, and can potentially serve as a platform to fabricate a molecularly tunable, self-repairable, flat peptide or hybrid film
URI
http://pubs.kist.re.kr/handle/201004/50884
ISSN
20411723
Appears in Collections:
KIST Publication > Article
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