Preparatuon of UV-Curable Gelatin derivatives for drug immobilization on polyurethane foam: development of wound dressing foam

Title
Preparatuon of UV-Curable Gelatin derivatives for drug immobilization on polyurethane foam: development of wound dressing foam
Authors
우희동박경태김은혜허윤정진홍편기도최창순이재관한동근나재운손태일
Keywords
azidophenyl-fish gelatin; wound dressing foam; epidermal growth factor (EGF); photo-cured; immobilization
Issue Date
2015-11
Publisher
Macromolecular research
Citation
VOL 23, NO 11, 994-1003
Abstract
UV-curable azidophenyl-fish gelatin (azidophenyl-f.gel) for developing a wound-dressing foam was prepared by introducing the photo-reactive azidophenyl group of N-4-(azido)-benzoyloxysuccinimide (ABS) to fish gelatin. The structure of prepared azidophenyl-f.gel was identified by 1H NMR and FTIR. The biocompatibility of azidophenyl-f.gel was demonstrated through a cell cytotoxicity experiment. In order to demonstrate that azidophenyl-f.gel is photo-cured on polyurethane foam by UV irradiation, a patterning test was conducted, and the protein immobilization of azidophenyl-f.gel was demonstrated through fluorescence microscopy by using FITC-BSA. The protein release pattern in relation to the concentration of azidophenyl-f.gel and the number of underlying layers of polyurethane foam was observed, and the effect of the protein release pattern on cell growth was observed through cell proliferation. Water absorbency and moisture vapour transmission rate (MVTR) tests were conducted to measure the performance of the wound dressing foam, and a wound healing effect was observed through an in vivo animal experiment. These results demonstrate that UV-curable azidophenyl-f.gel is biocompatible and can immobilize protein by UV irradiation. It is a useful material that can be applied to the underlying layer of wound dressing foam to induce rapid wound healing by gradually releasing immobilized protein.
URI
http://pubs.kist.re.kr/handle/201004/50930
ISSN
15985032
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE