Blood miRNAs as sensitive and specific biological indicators of environmental and occupational exposure to volatile organic compound (VOC)
- Blood miRNAs as sensitive and specific biological indicators of environmental and occupational exposure to volatile organic compound (VOC)
- 송미경; 류재천
- Volatile organic compounds; microRNA; Biomarker; Microarray
- Issue Date
- International journal of hygiene and environmental health
- VOL 218, NO 7, 590-602
- To date, there is still shortage of highly sensitive and specific minimally invasive biomarkers for assess-ment of environmental toxicants exposure. Because of the significance of microRNA (miRNA) in variousdiseases, circulating miRNAs in blood may be unique biomarkers for minimally invasive prediction of tox-icants exposure. We identified and validated characteristic miRNA expression profiles of human wholeblood in workers exposed to volatile organic compounds (VOCs) and compared the usefulness of miRNAindicator of VOCs with the effectiveness of the already used urinary biomarkers of occupational exposure.Using a microarray based approach we screened and detected deregulated miRNAs in their expression inworkers exposed to VOCs (toluene [TOL], xylene [XYL] and ethylbenzene [EBZ]). Total 169 workers fromfour dockyards were enrolled in current study, and 50 subjects of them were used for miRNA microarrayanalysis. We identified 467 miRNAs for TOL, 211 miRNAs for XYL, and 695 miRNAs for XYL as character-istic discernible exposure indicator, which could discerned each VOC from the control group with higheraccuracy, sensitivity, and specificity than urinary biomarkers. Current observations from this study pointout that the altered levels of circulating miRNAs can be a reliable novel, minimally invasive biologicalindicator of occupational exposure to VOCs.© 2015 Elsevier GmbH. All rights reserved.1. IntroductionVolatile organic compounds (VOCs) such as toluene (TOL),xylene (XYL) or ethylbenzene (EBZ) are the popular components oforganic solvents that are widely used in industries (Peng and Lin,2007). Exposure levels of these VOCs are very important indoorsand outdoors because they are widespread in the environment andthey could sometimes linger for years. Therefore, discovering sur-rogate markers associated with these VOCs are required to assessexposure risk.To date, biological monitoring of occupational exposure to VO
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