RNA structure: Tetraloops

Title
RNA structure: Tetraloops
Authors
Hae-Kap Cheong김낙균Chaejoon Cheong
Keywords
RNA; tetraloop; structure
Issue Date
2015-02
Publisher
eLife
Citation
, 1-6
Abstract
RNA hairpins are among the most common RNA secondary structural elements and are frequently capped by RNA tetraloops. RNA tetraloops are composed of characteristic four-loop nucleotides that form a compact and stable structure. While they can be formed by many different nucleotide sequences, UNCG (N=A, C, G, or U), GNRA (R=A or G), and CUUG tetraloops are found most often. Tetraloops usually help initiate RNA-folding processes and provide sites for tertiary contacts within or between RNAs and for protein binding, thereby facilitating the assembly of ribonucleoprotein particles. Tetraloop interactions can be either sequence- or structure-specific. Herein, we discuss the structures of RNA tetraloops and their interactions with other RNA structural motifs and with RNA-binding proteins.
URI
http://pubs.kist.re.kr/handle/201004/50990
ISSN
2050084X
Appears in Collections:
KIST Publication > ETC
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