synthesis of apoptotic chalcone analogues in HepG2 human hepatocellular carcinoma cells
- synthesis of apoptotic chalcone analogues in HepG2 human hepatocellular carcinoma cells
- cheon-soo park; yongchel ahn; dahae lee; 문성원; ki hyun kim; noriko yamabe; gwi seo hwang; hyuk jai jang; heesu lee; ki sung kang; 이재욱
- chalcone; anticancer; HepG2; Apoptosis
- Issue Date
- Bioorganic & medicinal chemistry letters
- VOL 25, 5705-5707
- Eight chalcone analogues were prepared and evaluated for their cytotoxic effects in human hepatoma HepG2 cells. Compound 5 had a potent cytotoxic effect. The percentage of apoptotic cells was significantly higher in compound 5-treated cells than in control cells. Exposure to compound 5 for 24 h induced cleavage of caspase-8 and -3, and poly (ADP-ribose) polymerase (PARP). Our findings suggest that compound 5 is the active chalcone analogue that contributes to cell death in HepG2 cells via the extrinsic apoptotic pathway.
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