synthesis of apoptotic chalcone analogues in HepG2 human hepatocellular carcinoma cells

Title
synthesis of apoptotic chalcone analogues in HepG2 human hepatocellular carcinoma cells
Authors
cheon-soo parkyongchel ahndahae lee문성원ki hyun kimnoriko yamabegwi seo hwanghyuk jai jangheesu leeki sung kang이재욱
Keywords
chalcone; anticancer; HepG2; Apoptosis
Issue Date
2015-10
Publisher
Bioorganic & medicinal chemistry letters
Citation
VOL 25, 5705-5707
Abstract
Eight chalcone analogues were prepared and evaluated for their cytotoxic effects in human hepatoma HepG2 cells. Compound 5 had a potent cytotoxic effect. The percentage of apoptotic cells was significantly higher in compound 5-treated cells than in control cells. Exposure to compound 5 for 24 h induced cleavage of caspase-8 and -3, and poly (ADP-ribose) polymerase (PARP). Our findings suggest that compound 5 is the active chalcone analogue that contributes to cell death in HepG2 cells via the extrinsic apoptotic pathway.
URI
http://pubs.kist.re.kr/handle/201004/50995
ISSN
0960894X
Appears in Collections:
KIST Publication > Article
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