TRPV1 on astrocytes rescues nigral dopamine neurons in Parkinson's disease via CNTF

Title
TRPV1 on astrocytes rescues nigral dopamine neurons in Parkinson's disease via CNTF
Authors
Jin H. NamEun S. ParkSo-Yoon WonYu A. LeeKyoung I. KimJae Y. JeongJeong Y. BaekEun J. ChoMinyoung JinYoung C. ChungByoung D. LeeSung Hyun KimEung-Gook KimKyunghee ByunBonghee Lee우동호이창준Sang R. KimEugene BokYoon-Seong KimTae-Beom AhnHyuk Wan KoSaurav BrahmachariOlga PletinkovaJuan C. TroconsoValina L. DawsonTed M. DawsonByung K. Jin
Keywords
Parkinson's disease; TRPV1; astrocyte; ciliary neurotrophic factor (CNTF); dopamine neurons
Issue Date
2015-12
Publisher
Brain : a journal of neurology
Citation
VOL 138, NO 12, 3610-3622
Abstract
Currently there is no neuroprotective or neurorestorative therapy for Parkinson’s disease. Here we report that transient receptor potential vanilloid 1 (TRPV1) on astrocytes mediates endogenous production of ciliary neurotrophic factor (CNTF), which prevents the active degeneration of dopamine neurons and leads to behavioural recovery through CNTF receptor alpha (CNTFRa) on nigral dopamine neurons in both the MPP+ -lesioned or adeno-associated virus a-synuclein rat models of Parkinson’s disease. Western blot and immunohistochemical analysis of human post-mortem substantia nigra from Parkinson’s disease suggests that this endogenous neuroprotective system (TRPV1 and CNTF on astrocytes, and CNTFRa on dopamine neurons) might have relevance to human Parkinson’s disease. Our results suggest that activation of astrocytic TRPV1 activates endogenous neuroprotective machinery in vivo and that it is a novel therapeutic target for the treatment of Parkinson’s disease.
URI
http://pubs.kist.re.kr/handle/201004/51111
ISSN
00068950
Appears in Collections:
KIST Publication > Article
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