Preliminary study on implantable inductive-type sensor for continuous monitoring of intraocular pressure

Title
Preliminary study on implantable inductive-type sensor for continuous monitoring of intraocular pressure
Authors
김용우김미정박기호정진욱김석환장철인이수현김재헌이석강지윤
Keywords
continuous monitoring; glaucoma; intraocular pressure; implantable sensor.
Issue Date
2015-12
Publisher
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
Citation
VOL 43, 830-837
Abstract
Background: This study aims to validate the performance and biocompatibility of an implantable inductive-type sensor for continuous monitoring of intraocular pressure (IOP) Methods: The sensor is composed of a top layer integrated with an inductor and capacitor circuit, and a bottom layer integrated with ferrite. With IOP change, the sensor’s bottom layer is mechanically deflected, which changes the distance between the bottom-layer ferrite and top-layer inductor, resulting in an alteration of inductance magnitude and the resonant frequency (RF). In-vitro measurement was conducted via air pressurization in a sealing jig (n = 3). Subsequently, the sensor was implanted into the anterior chamber of a rabbit eye. In-vivo measurement was performed while the IOP was elevated by infusion of balanced salt solution (BSS, 6 μL/ min). Smaller-sized sensors later were implanted into two rabbit eyes, which were microscopically examined at 2, 4 and 8 weeks post-implantation. The eyes were then immediately enucleated for histological examination. Results: The in-vitro measurement showed a significant RF shift as pressure in the jig was increased from 0 mmHg to 60 mmHg (average initial frequency: 10.86 MHz, average shift: 403 kHz). The in-vivo measurement also showed an RF decrease, from 12.80 MHz to 12.67 MHz, as the pressure was increased from 10 mmHg to 20 mmHg. Microscopic in-vivo evaluations and histological exams, performed at intervals up to 8 weeks post-implantation, showed no evidence of significant inflammation or deformity of the ocular-tissue structures. Conclusions: The implantable inductive-type IOP sensor demonstrated wireless pressure-sensing ability and favourable biocompatibility in the rabbit eye.
URI
http://pubs.kist.re.kr/handle/201004/58224
ISSN
14426404
Appears in Collections:
KIST Publication > Article
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