Long-term clinical study and multiscale analysis of in vivo biodegradation mechanism of Mg alloy

Title
Long-term clinical study and multiscale analysis of in vivo biodegradation mechanism of Mg alloy
Authors
이지욱한형섭한경진박지민전호정옥명렬석현광안재평이경은이동호양석조조성윤차필령권훈남태현한지혜로노형진이강식김유찬Diego Mantovani
Keywords
biodegradable implant; bone formation; clinical application
Issue Date
2016-01
Publisher
Proceedings of the National Academy of Sciences of the United States of America
Abstract
There has been a tremendous amount of research in the past decade to optimize the mechanical properties and degradation behavior of the biodegradable Mg alloy for orthopedic implant. Despite the feasibility of degrading implant, the lack of fundamental understanding about biocompatibility and underlying bone formation mechanism is currently limiting the use in clinical applications. Herein, we report the result of long-term clinical study and systematic investigation of bone formation mechanism of the biodegradable Mg-5wt%Ca-1wt%Zn alloy implant through simultaneous observation of changes in element composition and crystallinity within degrading interface at hierarchical levels. Controlled degradation of Mg-5wt%Ca-1wt%Zn alloy results in the formation of biomimicking calcification matrix at the degrading interface to initiate the bone formation process. This process facilitates early bone healing and allows the complete replacement of biodegradable Mg implant by the new bone within 1 y of implantation, as demonstrated in 53 cases of successful long-term clinical study.
URI
http://pubs.kist.re.kr/handle/201004/58359
ISSN
00278424
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KIST Publication > Article
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