Comparison of the Wound-Healing Effects of Ginsenosides, their Metabolites, and Aglycones

Title
Comparison of the Wound-Healing Effects of Ginsenosides, their Metabolites, and Aglycones
Authors
박준연유환이다혜허원상황기서노경태김기현함정엽Noriko Yamabe김영훈강기성
Keywords
Ginsenosides; Tube formation; Sapogenin; Wound healing
Issue Date
2016-01
Publisher
Bulletin of the Korean Chemical Society
Citation
VOL 37, 52-55
Abstract
The effect of ginsenosides, their metabolites, and aglycones on tube formation in human umbilical vein vascular endothelial cells (HUVEC) was investigated to identify ways to potentially enhance wound healing. Of the tested compounds, sapogenins, aglycones of ginsenosides, promoted tube formation, whereas ginsenosides and their metabolites had no effect or inhibitory effects on tube formation. Treatment of HUVEC at concentrations of 6.25 and 12.5 μM 20(S)-protopanaxadiol (PPD) significantly increased tube formation by 34 and 35%, respectively. PPD also had a pronounced effect on the speed of wound closure in mouse dermal wounds.
URI
http://pubs.kist.re.kr/handle/201004/58517
ISSN
02532964
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE