Diospyros kaki Extract Inhibits Alkali Burn-Induced Corneal Neovascularization

Title
Diospyros kaki Extract Inhibits Alkali Burn-Induced Corneal Neovascularization
Authors
Yang Sung JaeJo Hyoung김경아안홍열강석우정상훈
Keywords
alkali burn; angiogenic factors; corneal neovascularization; Diospyros kaki; eye diseases
Issue Date
2016-01
Publisher
Journal of medicinal food
Citation
VOL 19, NO 1, 106-109
Abstract
The purpose of this study was to evaluate the effect of ethanol extract of Diospyros kaki (EEDK) leaves on corneal neovascularization (CoNV) in rats. One week after the alkali burns in the corneas, the CoNV area coverage in the CoNV-positive control group, 100 mg/kg EEDK group, and 200 mg/kg EEDK group was 43.3% ± 5.5%, 337.7% ± 2.5%, and 27.2% ± 4.3%, respectively. The areas of CoNV in the EEDK-treated groups were significantly different from those of the CoNV group. EEDK significantly attenuated the upregulation of vascular endothelial growth factor, fibroblast growth factor, interleukin-6, and matrix metalloproteinase-2 (MMP-2) protein levels. Orally administrated D. kaki inhibited CoNV development in rats.
URI
http://pubs.kist.re.kr/handle/201004/58526
ISSN
1096620X
Appears in Collections:
KIST Publication > Article
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