Diospyros kaki Extract Inhibits Alkali Burn-Induced Corneal Neovascularization
- Diospyros kaki Extract Inhibits Alkali Burn-Induced Corneal Neovascularization
- Yang Sung Jae; Jo Hyoung; 김경아; 안홍열; 강석우; 정상훈
- alkali burn; angiogenic factors; corneal neovascularization; Diospyros kaki; eye diseases
- Issue Date
- Journal of medicinal food
- VOL 19, NO 1, 106-109
- The purpose of this study was to evaluate the effect of ethanol extract of Diospyros kaki (EEDK) leaves on corneal neovascularization (CoNV) in rats. One week after the alkali burns in the corneas, the CoNV area coverage in the CoNV-positive control group, 100 mg/kg EEDK group, and 200 mg/kg EEDK group was 43.3% ± 5.5%, 337.7% ± 2.5%, and 27.2% ± 4.3%, respectively. The areas of CoNV in the EEDK-treated groups were significantly different from those of the CoNV group. EEDK significantly attenuated the upregulation of vascular endothelial growth factor, fibroblast growth factor, interleukin-6, and matrix metalloproteinase-2 (MMP-2) protein levels. Orally administrated D. kaki inhibited CoNV development in rats.
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