gambogic acid induces apoptotic cell death in T98G glioma cells
- gambogic acid induces apoptotic cell death in T98G glioma cells
- Mya Thida; Dae Won Kim; Thi Thu Thuy Tran; Minh Quan Pham; Heesu Lee; Inki Kim; 이재욱
- gambogic acid; reactive oxygen species; glioblastoma; apoptosis; anticancer
- Issue Date
- Bioorganic & medicinal chemistry letters
- VOL 26, 1097-1101
- Gambogic acid (GA), a natural product with a xanthone structure, has a broad range of anti-proliferative effects on cancer cell lines. We evaluated GA for its cytotoxic effects on T98G glioblastoma cells. GA exhibited potent anti-proliferative activity and induced apoptosis in T98G glioblastoma cells in a dose-dependent manner. Incubation of cells with GA revealed apoptotic features including increased Bax and AIF expression, cytochrome c release, and cleavage of caspase-3, -8, -9, and PARP, while Bcl-2 expression was downregulated. Furthermore, GA induced reactive oxygen species (ROS) generation in T98G cells. Our results indicate that GA increases Bax- and AIF-associated apoptotic signaling in glioblastoma cells.
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