gambogic acid induces apoptotic cell death in T98G glioma cells

Title
gambogic acid induces apoptotic cell death in T98G glioma cells
Authors
Mya ThidaDae Won KimThi Thu Thuy TranMinh Quan PhamHeesu LeeInki Kim이재욱
Keywords
gambogic acid; reactive oxygen species; glioblastoma; apoptosis; anticancer
Issue Date
2016-01
Publisher
Bioorganic & medicinal chemistry letters
Citation
VOL 26, 1097-1101
Abstract
Gambogic acid (GA), a natural product with a xanthone structure, has a broad range of anti-proliferative effects on cancer cell lines. We evaluated GA for its cytotoxic effects on T98G glioblastoma cells. GA exhibited potent anti-proliferative activity and induced apoptosis in T98G glioblastoma cells in a dose-dependent manner. Incubation of cells with GA revealed apoptotic features including increased Bax and AIF expression, cytochrome c release, and cleavage of caspase-3, -8, -9, and PARP, while Bcl-2 expression was downregulated. Furthermore, GA induced reactive oxygen species (ROS) generation in T98G cells. Our results indicate that GA increases Bax- and AIF-associated apoptotic signaling in glioblastoma cells.
URI
http://pubs.kist.re.kr/handle/201004/58562
ISSN
0960894X
Appears in Collections:
KIST Publication > Article
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