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dc.contributor.authorMya Thida-
dc.contributor.authorDae Won Kim-
dc.contributor.authorThi Thu Thuy Tran-
dc.contributor.authorMinh Quan Pham-
dc.contributor.authorHeesu Lee-
dc.contributor.authorInki Kim-
dc.contributor.author이재욱-
dc.date.accessioned2016-01-31T17:00:03Z-
dc.date.available2016-01-31T17:00:03Z-
dc.date.issued201601-
dc.identifier.citationVOL 26, 1097-1101-
dc.identifier.issn0960894X-
dc.identifier.other46146-
dc.identifier.urihttp://pubs.kist.re.kr/handle/201004/58562-
dc.description.abstractGambogic acid (GA), a natural product with a xanthone structure, has a broad range of anti-proliferative effects on cancer cell lines. We evaluated GA for its cytotoxic effects on T98G glioblastoma cells. GA exhibited potent anti-proliferative activity and induced apoptosis in T98G glioblastoma cells in a dose-dependent manner. Incubation of cells with GA revealed apoptotic features including increased Bax and AIF expression, cytochrome c release, and cleavage of caspase-3, -8, -9, and PARP, while Bcl-2 expression was downregulated. Furthermore, GA induced reactive oxygen species (ROS) generation in T98G cells. Our results indicate that GA increases Bax- and AIF-associated apoptotic signaling in glioblastoma cells.-
dc.publisherBioorganic & medicinal chemistry letters-
dc.subjectgambogic acid-
dc.subjectreactive oxygen species-
dc.subjectglioblastoma-
dc.subjectapoptosis-
dc.subjectanticancer-
dc.titlegambogic acid induces apoptotic cell death in T98G glioma cells-
dc.typeArticle-
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