Age-dependent inverse correlations in CSF and plasma amyloid-β(1?42) concentrations prior to amyloid plaque deposition in the brain of 3xTg-AD mice

Title
Age-dependent inverse correlations in CSF and plasma amyloid-β(1?42) concentrations prior to amyloid plaque deposition in the brain of 3xTg-AD mice
Authors
조수민이세진양승훈김혜연이지수김현진김지윤백승엽윤진김도희김윤경조약돌우지완김태송김영수
Keywords
치매; 알츠하이머; 혈액진단; dementia; Alzheimer; blood test
Issue Date
2016-02
Publisher
Scientific Reports
Citation
VOL 6, 20185
Abstract
Amyloid-beta (A beta) plays a critical role as a biomarker in Alzheimer's disease (AD) diagnosis. In addition to its diagnostic potential in the brain, recent studies have suggested that changes of A beta level in the plasma can possibly indicate AD onset. In this study, we found that plasma A beta(1-42) concentration increases with age, while the concentration of A beta(1-42) in the cerebrospinal fluid (CSF) decreases in APP(swe), PS1(M146V) and Tau(P301L) transgenic (3xTg-AD) mice, if measurements were made before formation of ThS-positive plaques in the brain. Our data suggests that there is an inverse correlations between the plasma and CSF A beta(1-42) levels until plaques form in transgenic mice's brains and that the plasma A beta concentration possesses the diagnostic potential as a biomarker for diagnosis of early AD stages
URI
http://pubs.kist.re.kr/handle/201004/58651
ISSN
20452322
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