Evaluation of Chemical Interactions between Small Molecules in the Gas Phase Using Chemical Force Microscopy

Title
Evaluation of Chemical Interactions between Small Molecules in the Gas Phase Using Chemical Force Microscopy
Authors
이지은주수미김인태정선화민선준김철기심상준김상경
Keywords
small molecule; specific receptor; chemical force microscopy; humidity control; hydrophilicity; hydrophobicity
Issue Date
2015-12
Publisher
Sensors
Citation
VOL 15, 30683-30692
Abstract
Chemical force microscopy analyzes the interactions between various chemical/biochemical moieties in situ. In this work we examined force-distance curves and lateral force to measure the interaction between modified AFM tips and differently functionalized molecular monolayers. Especially for the measurements in gas phase, we investigated the effect of humidity on the analysis of force-distance curves and the images in lateral force mode. Flat chemical patterns composed of different functional groups were made through micro-contact printing and lateral force mode provided more resolved analysis of the chemical patterns. From the images of 1-octadecanethiol/11-mercapto-1-undecanoic acid patterns, the amine group functionalized tip brought out higher contrast of the patterns than an intact silicon nitride tip owing to the additional chemical interaction between carboxyl and amine groups. For more complex chemical interactions, relative chemical affinities toward specific peptides were assessed on the pattern of 1-octadecanethiol/phenyl-terminated alkanethiol. The lateral image of chemical force microscopy reflected specific preference of a peptide to phenyl group as well as the hydrophobic interaction.
URI
http://pubs.kist.re.kr/handle/201004/58771
ISSN
14248220
Appears in Collections:
KIST Publication > Article
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