Growth factors-loaded stents modified with hyaluronic acid andheparin for induction of rapid and tight re-endothelialization

Title
Growth factors-loaded stents modified with hyaluronic acid andheparin for induction of rapid and tight re-endothelialization
Authors
최동훈강성남김성민Samy Olivier GobaaBang Ju ParkIk Hwan Kim정윤기한동근
Keywords
Re-endothelialization; Stent; Hyaluronic acid; Heparin; Growth factor; Dopamine
Issue Date
2016-03
Publisher
Colloids and surfaces. B, Biointerfaces
Citation
VOL 141, 602-610
Abstract
Rapid re-endothelialization of damaged vessel lining efficiently prevents restenosis and thrombosis and restores original vascular functions. In this study, we designed a novel metallic stent with a heparin-modified surface and used different methods, including 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and divinyl sulfone (DVS), to load growth factors. First we loaded heparin into a dopamine-conjugated hyaluronic acid (HA) coating to serve as a growth factor reservoir. In a second step, we took advantage of the heparin-binding domain of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) to gain advanced re-endothelialization capabilities. We demonstrated that DVS technique offered higher amount of growth factor loading. In vitro assessment also showed better capillary-like structure formation and localized gap junctions when DVS coating was employed. This study suggested that growth factor loaded stent modified by HA and heparin provided the advantage to rapid and tight restoration of endothelium.
URI
http://pubs.kist.re.kr/handle/201004/58782
ISSN
09277765
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE