Combinatorial Dansyl Library and its Applications to pH-Responsive Probes

Title
Combinatorial Dansyl Library and its Applications to pH-Responsive Probes
Authors
홍성철디라제무라레이준석
Keywords
fluorescence library; dansyl; imaging; pH indicator
Issue Date
2016-05
Publisher
Combinatorial chemistry & high throughput screening
Citation
VOL 19, NO 5, 347-352
Abstract
Herein, we report the first 48-membered, dansyl-based, combinatorial fluorescent library. From the electronic and structural properties of the probes, we analyzed their optical properties and chemical yields, with an average of 49 %. The molecules were examined for their pH responses, and DS-2 and DS-45 showed blue-shifts, whereas DS-7 and DS-40 showed red-shifts in wavelength with increasing pH. Finally, cell permeability was investigated by treating SNU-2292 cells. Our results demonstrate the potential application of this library in biosensors, bio-imaging and pH indicators.
URI
http://pubs.kist.re.kr/handle/201004/58901
ISSN
13862073
Appears in Collections:
KIST Publication > Article
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