Secreted semaphorins modulate synaptic transmission in the adult hippocampus

Title
Secreted semaphorins modulate synaptic transmission in the adult hippocampus
Authors
김종현Amar SahayJehuda P. SepkutyEdward ChoRichard L. HuganirDavid D. GintyAlex L. Kolodkin
Issue Date
2005-04
Publisher
Journal of neuroscience
Citation
VOL 25, NO 14, 3613-3620
Abstract
Modulation of synaptic activity is critical for neural circuit function and behavior. The semaphorins are a large, phylogenetically conserved protein family with important roles in neural development. However, semaphorin function in the adult brain has yet to be determined. Here, we show that the coreceptors for secreted semaphorins, the neuropilins, are found at synapses and localize to molecular layers of the adult mouse hippocampus and accessory olfactory cortex. Moreover, application of the secreted semaphorin Sema3F to acute hippocampal slices modulates both the frequency and amplitude of miniature EPSCs in granule cells of the dentate gyrus and pyramidal neurons of CA1. Finally, we show that mice lacking Sema3F are prone to seizures. These results suggest a novel role for semaphorins as synaptic modulators and illustrate the diverse repertoire of these guidance cues in both the formation and function of neural circuits.
URI
http://pubs.kist.re.kr/handle/201004/59176
ISSN
02706474
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KIST Publication > Article
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