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dc.contributor.author김종현-
dc.contributor.authorJohn E. Lisman-
dc.date.accessioned2016-05-24T08:25:44Z-
dc.date.available2016-05-24T08:25:44Z-
dc.date.issued1999-06-
dc.identifier.citationVOL 19, 4314-4324-
dc.identifier.issn02706474-
dc.identifier.other46441-
dc.identifier.urihttp://pubs.kist.re.kr/handle/201004/59179-
dc.description.abstractThe role of actin filaments in synaptic function has been studied in the CA1 region of the rat hippocampal slice. Bath application (2 hr) of the actin polymerization inhibitor latrunculin B did not substantially affect the shape of dendrites or spines. However, this and other drugs that affect actin did affect synaptic function. Bath-applied latrunculin B reduced the synaptic response. Several lines of evidence indicate that a component of this effect is presynaptic. To specifically test for a postsynaptic role for actin, latrunculin B or phalloidin, an actin filament stabilizer, was perfused into the postsynaptic neuron. The magnitude of long-term potentiation (LTP) was decreased at times when baseline transmission was not yet affected. Longer applications produced a decrease in baseline AMPA receptor (AMPAR)-mediated transmission. The magnitude of the NMDA receptor-mediated transmission was unaffected, indicating a specific effect on the AMPAR. These results suggest that postsynaptic actin filaments are involved in a dynamic process required to maintain AMPAR-mediated transmission and to enhance it during LTP.-
dc.publisherJournal of neuroscience-
dc.titleA role of actin filament in synaptic transmission and long-term potentiation-
dc.typeArticle-
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