Proteome-scale identification and regulation ofmotif-mediated interactions
- Proteome-scale identification and regulation ofmotif-mediated interactions
- Proteome; Peptide motif; protein-protein interaction
- Issue Date
- 2018 한국생물공학회 추계학술발표대회 및 국제심포지엄
- As proteins perform pivotal roles in cells, tightly and accurately controlled interactions among proteins orchestrate essential cellular processes, from development to cell death. Thus, not surprisingly, protein-protein interactions (PPIs) have caught particular attention for deeper understanding of cellular mechanisms as well as for the development of novel strategies to target various types of diseases. Nevertheless, the motif-mediated interactions (MMIs) are among the most underrepresented types of interactions in available interaction data, largely due to technical difficulties inherent in the properties of MMIs. As the increasing recognition of the vital roles of MMIs in biology, several systematic approaches have recently been developed to detect novel binding surfaces based on the MMIs. Here, peptide-based proteome-scale systematic approaches (both target-based and phenotypic-based screening) to identify novel PPIs are introduced. These cutting-edge strategies prove to be powerful to identify low-affinity interactions, and were further harnessed to uncover novel target PPIs by intracellular screening with cancer cells.
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