3D Printed Porous Methacrylate/Silica Hybrid Scaffold for Bone Substitution

Title
3D Printed Porous Methacrylate/Silica Hybrid Scaffold for Bone Substitution
Authors
정영미정지홍류진김태희이수진Sum Brian S. T.Li SiweiLi ZhenlunStevens Molly M.Georgiou Theoni K.Jones Julian R.
Keywords
3D printing; Biomaterials; Bone substitutes; Hybrids; Sol-gels
Issue Date
2021-05
Publisher
Advanced Healthcare Materials
Abstract
Inorganic?organic hybrid biomaterials made with star polymer poly(methyl methacrylate­co­3­(trimethoxysilyl)propyl methacrylate) and silica, which show promising mechanical properties, are 3D printed as bone substitutes for the first time, by direct ink writing of the sol. Three different inorganic:organic ratios of poly(methyl methacrylate­co­3­(trimethoxysilyl)propyl methacrylate)­star­SiO2 hybrid inks are printed with pore channels in the range of 100?200 ?m. Mechanical properties of the 3D printed scaffolds fall within the range of trabecular bone, and MC3T3 pre­osteoblast cells are able to adhere to the scaffolds in vitro, regardless of their compositions. Osteogenic and angiogenic properties of the hybrid scaffolds are shown using a rat calvarial defect model. Hybrid scaffolds with 40:60 inorganic:organic composition are able to instigate new vascularized bone formation within its pore channels and polarize macrophages toward M2 phenotype. 3D printing inorganic?organic hybrids with sophisticated polymer structure opens up possibilities to produce novel bone graft materials.
URI
http://pubs.kist.re.kr/handle/201004/64530
ISSN
2192-2640
Appears in Collections:
KIST Publication > Article
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