Neuroprotective Xanthones from the Root Bark of Cudrania tricuspidata

Title
Neuroprotective Xanthones from the Root Bark of Cudrania tricuspidata
Authors
권재영Nguyen Tuan HiepDong-Woo KimBang Yeon HwangHak Ju LeeWoongchon MarDongho Lee
Issue Date
2014-08
Publisher
Journal of natural products
Citation
VOL 77-1901
Abstract
Seventeen new prenylated xanthones (1-17) were isolated from an ethyl acetate-soluble extract of root bark of Cudrania tricuspidata together with 17 previously identified xanthones. The structures of the new compounds were elucidated by spectroscopic methods. Six new compounds (3, 7, 8, 9, 15, and 16) and six known compounds (18-23) showed neuroprotective effects against 6-hydroxydopamine-induced cell death in human neuroblastoma SH-SYSY cells, with EC50 values of 0.7-16.6 mu M.
URI
http://pubs.kist.re.kr/handle/201004/64905
ISSN
0163-3864
Appears in Collections:
KIST Publication > Article
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