Isoflavones with neuroprotective activities from fruits of Cudrania tricuspidata
- Isoflavones with neuroprotective activities from fruits of Cudrania tricuspidata
- 권재영; Nguyen Tuan Hiep; Dong-Woo Kim; Bang Yeon Hwang; Hak-Ju Lee; Woongchon Mar; Dongho Lee
- Issue Date
- VOL 111-148
- Ten isoflavones, cudraisoflavones B-K (1-10), together with 27 known isoflavones, were isolated from the EtOAc soluble extract of fruits of Cudrania tricuspidata. The structures of compounds 1-10 were elucidated on the basis of MS and NMR spectroscopic data, including 2D NMR experiments. Compounds 7-9 and three known (11-13) compounds showed neuroprotective activity against 6-hydroxydopamine induced cell death in human neuroblastoma SH-SY5Y cells, with EC50 values of 0.5-9.2 mu M.
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